Α-actinin-4 Is Required for Normal Podocyte Adhesion
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چکیده
Savita V. Dandapani, Hikaru Sugimoto, Benjamin D. Matthews, Robert J. Kolb, Sumita Sinha Robert E. Gerszten, Jing Zhou, Donald E. Ingber, Raghu Kalluri, Martin R. Pollak Department of Genetics, Harvard Medical School, Boston, MA, Renal Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA Division of Matrix Biology, Beth Israel Deaconess Medical Center, Boston, MA, Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, Vascular Biology Program, Departments of Pathology and Surgery, Children’s Hospital, Boston, MA, Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA Running title: α-Actinin-4 in Podocyte Adhesion Address correspondence to: Martin R. Pollak, 4 Blackfan Circle, Boston, MA 02115,Tel.617-525 5840, Fax. 617 525-5841, E-mail: [email protected]
منابع مشابه
Alpha-actinin-4 is required for normal podocyte adhesion.
Mutations in the alpha-actinin-4 gene ACTN4 cause an autosomal dominant human kidney disease. Mice deficient in alpha-actinin-4 develop a recessive phenotype characterized by kidney failure, proteinuria, glomerulosclerosis, and retraction of glomerular podocyte foot processes. However, the mechanism by which alpha-actinin-4 deficiency leads to glomerular disease has not been defined. Here, we e...
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Focal segmental glomerulosclerosis (FSGS) is an important cause of proteinuria and nephrotic syndrome in humans. The pathogenesis of FSGS may be associated with glomerular visceral epithelial cell (GEC; podocyte) injury, leading to apoptosis, detachment, and "podocytopenia", followed by glomerulosclerosis. Mutations in α-actinin-4 are associated with FSGS in humans. In cultured GECs, α-actinin-...
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BACKGROUND The actin cytoskeleton in podocytes is essential for the maintenance of its normal structure and function. Its disruption is a feature of podocyte foot-process effacement and is associated with proteinuria. α-Actinin-4 in podocytes serves as a linker protein binding the actin filaments of the cytoskeleton. METHODS To investigate the effect of ginseng total saponin (GTS) on the path...
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تاریخ انتشار 2006